The Nutritional Immunology and Molecular Medicine Laboratory uses innovation to tackle global challenges in infectious, immune-mediated and chronic inflammatory disease research. We combine computational approaches with pre-clinical and clinical experimentation to transition new biological knowledge into disruptive therapeutics for human diseases.

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Principal Investigators

Bassaganya-Riera Josep

Josep Bassaganya-Riera

Director and Research Professor, NIMML

Hontecillas-Magarzo Raquel

Raquel Hontecillas-Magarzo

Research Professor

Publications

2018

  • Verma M, Hontecillias R, Abedi V, Leber A, Lu P, Tubau-Juni N, Bassaganya-Riera J. From Nutritional Immunology to Drug Development. In: Accelerated Path to Cures . 1st ed. Springer; 2018:41–56. https://doi.org/10.1007/978-3-319-73238-1.
  • Bassaganya-Riera J, Hontecillias R. Introduction to accelerated path to cures and precision medicine in inflammatory bowel disease . In: Accelerated Path to Cures . 1st ed. Springer; 2018:1–6. https://doi.org/10.1007/978-3-319-73238-1_1.
  • Barrett C, Bassaganya-Riera J, Hontecillias R. Interviewed by Rosplock D. Virginia Tech researchers awarded $1.7M to support fast, effective responses to biological attacks. VT News. 2018. https://vtnews.vt.edu/articles/2018/04/bi-biodefensegrant.html.
  • Leber A, Hontecillias R, Tubau-Juni N, Zoccoli-Rodriguez V, Abedi V, Bassaganya-Riera J. NLRX1 Modulates Immunometabolic Mechanisms Controlling the Host–Gut Microbiota Interactions during Inflammatory Bowel Disease. Frontiers in Immunology. 2018;9:363. https://doi.org/10.3389/fimmu.2018.00363.
  • Bassaganya-Riera J. Accelerated Path to Cures. 1st ed. Springer International Publishing ; 2018. https://doi.org/10.1007/978-3-319-73238-1.

2017

2016

  • Abedi V, Lu P, Hontecillas-Magarzo R, Verma M, Vess G, Philipson CW, Carbo A, Leber A, Juni NT, Hoops S, Bassaganya-Riera J. Phase III Placebo-Controlled, Randomized Clinical Trial with Synthetic Crohn's disease Patients to Evaluate Treatment Response. In: Emerging Trends in Applications and Infrastructures for Computational Biology, Bioinformatics, and Systems Biology. Elsevier/MK; 2016:441–427. https://doi.org/10.1016/B978-0-12-804203-8.00028-6.
  • Coutermarsh-Ott S, Simmons A, Capria V, LeRoith T, Wilson JE, Heid B, Philipson CW, Qin Q, Hontecillas-Magarzo R, Bassaganya-Riera J, Ting JP-Y, Dervisis N, Allen IC. NLRX1 suppresses tumorigenesis and attenuates histiocytic sarcoma through the negative regulation of NF-lambda B signaling. ONCOTARGET. 2016;7(22):33096–33110. https://doi.org/10.18632/oncotarget.8861.
  • Leber A, Abedi V, Hontecillas R, Viladomiu M, Hoops S, Ciupe S, Caughman J, Andrew T, Bassaganya-Riera J. Bistability analyses of CD4+T follicular helper and regulatory cells during Helicobacter pylori infection. JOURNAL OF THEORETICAL BIOLOGY. 2016;398:74–84. https://doi.org/10.1016/j.jtbi.2016.02.036.
  • Kronsteiner B, Bassaganya-Riera J, Philipson C, Viladomiu M, Carbo A, Abedi V, Hontecillas R. Systems-wide analyses of mucosal immune responses to Helicobacter pylori at the interface between pathogenicity and symbiosis. Gut microbes. 2016;7(1):3–21. https://doi.org/10.1080/19490976.2015.1116673.
  • Verma M, Hontecillas R, Abedi V, Leber A, Tubau-Juni N, Philipson C, Carbo A, Bassaganya-Riera J. Modeling-Enabled Systems Nutritional Immunology. Frontiers in nutrition. 2016;3:5. https://doi.org/10.3389/fnut.2016.00005.

2015

  • Bassaganya-Riera J, Hontecillas R, Abedi V, Carbo A, Philipson C, Hoops S. Computational Modeling. In: Computational Immunology: Models and Tools. 1st ed. 2015:9–29.
  • Michalak P, Sobral BW, Abedi V, Kim YB, Deng X, Philipson C, Viladomiu M, Lu P, Wendelsdorf K, Hontecillas R, Bassaganya-Riera J. From Big Data Analytics and Network Inference to Systems Modeling. In: Computational Immunology: Models and Tools. 2015.
  • Hoops S, Sobral BW, Michalak P, Abedi V, Kronsteiner B, Hontecillas R, Viladomiu M, Bassaganya-Riera J. Immunoinformatics cybernfrastructure for modeling and analytics. In: Computational Immunology: Models and Tools. 1st ed. 2015:45–61.
  • Bassaganya-Riera J, Hontecillas R. Introduction to Computational Immunology. In: Computational Immunology: Models and Tools. 1st ed. 2015:1–8.
  • Abedi V, Hoops S, Hontecillas R, Carbo A, Philipson C, Viladomiu M, Leber A, Lu P, Bassaganya-Riera J. Modeling exercises. In: Computational Immunology: Models and Tools. 2015.
  • Hoops S, Hontecillas R, Abedi V, Leber A, Philipson C, Carbo A, Bassaganya-Riera J. Ordinary Differential Equations (ODE) based Modeling. In: Computational Immunology: Models and Tools. 2015.
  • Hontecillas-Magarzo R, Bassaganya-Riera J, Philipson C, Leber A, Viladomiu M, Carbo A, Wendelsdorf K, Hoops S. Use of Computational Modeling in Immunological Research. In: Computational Immunology: Models and Tools. 2015.
  • Philipson CW, Bassaganya-Riera J, Viladomiu M, Kronsteiner B, Abedi V, Hoops S, Michalak P, Kang L, Girardin SE, Hontecillas R. Modeling the Regulatory Mechanisms by Which NLRX1 Modulates Innate Immune Responses to Helicobacter pylori Infection. PLOS ONE. 2015;10(9). https://doi.org/10.1371/journal.pone.0137839.
  • Lu P, Abedi V, Mei Y, Hontecillas R, Hoops S, Carbo A, Bassaganya-Riera J. Supervised learning methods in modeling of CD4+T cell heterogeneity. BIODATA MINING. 2015;8. https://doi.org/10.1186/s13040-015-0060-6.
  • Bassaganya-Riera J, Guri AJ, Hontecillas R. Method of synergistically enhancing the therapeutic efficacy and safety of medications through a combination therapy. . 2015. https://patents.google.com/patent/US9119881B2.
  • Mei Y, Abedi V, Carbo A, Zhang X, Lu P, Philipson C, Hontecillas R, Hoops S, Liles N, Bassaganya-Riera J. Multiscale modeling of mucosal immune responses. BMC BIOINFORMATICS. 2015;16. https://doi.org/10.1186/1471-2105-16-S12-S2.
  • Alam MM, Abedi V, Bassaganya-Riera J, Wendelsdorf KV, Bisset KR, Deng X, Eubank SG, Hontecillas-Magarzo R, Hoops S, Marathe MV. Agent-Based Modeling and High Performance Computing. In: Computational Immunology: Models and Tools. Elsevier; 2015:79–112. http://store.elsevier.com/product.jsp?isbn=9780128036976.
  • Alam MM, Deng X, Philipson C, Bassaganya-Riera J, Bisset KR, Carbo A, Eubank SG, Hontecillas-Magarzo R, Hoops S, Mei Y, Abedi V, Marathe MV. Sensitivity Analysis of an ENteric Immunity SImulator (ENISI)-based Model of Immune Responses to Helicobacter pylori Infection. PLOS One. 2015;10(9):e0136139. https://doi.org/10.1371/journal.pone.0136139.
  • Lu P, Abedi V, Mei Y, Hontecillas R, Philipson C, Hoops S, Carbo A, Bassaganya-Riera J. Supervised Learning with Artificial Neural Network in Modeling of Cell Differentiation Process. In: Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology. Morgan Kaufmann; 2015.
  • Leber A, Viladomiu M, Hontecillas R, Abedi V, Philipson C, Hoops S, Howard B, Bassaganya-Riera J. Systems Modeling of Interactions between Mucosal Immunity and the Gut Microbiome during Clostridium difficile Infection. PLOS ONE. 2015;10(7). https://doi.org/10.1371/journal.pone.0134849.
  • Viladomiu M, Hontecillas R, Bassaganya-Riera J. Modulation of inflammation and immunity by dietary conjugated linoleic acid. EUROPEAN JOURNAL OF PHARMACOLOGY. 2015;785:87–95. https://doi.org/10.1016/j.ejphar.2015.03.095.
  • Lewis SN, Garcia Z, Hontecillas R, Bassaganya-Riera J, Bevan DR. Pharmacophore modeling improves virtual screening for novel peroxisome proliferator-activated receptor-gamma ligands. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN. 2015;29(5):421–439. https://doi.org/10.1007/s10822-015-9831-x.
  • Abedi V, Hontecillas R, Hoops S, Liles N, Carbo A, Lu P, Philipson C, Bassaganya-Riera J. ENISI Multiscale modeling of mucosal immune responses driven by high performance computing. Presented at the IEEE International Conference on Bioinformatics and Biomedicine, Washington, DC; 2015. https://doi.org/10.1109/BIBM.2015.7359768.
  • Mei Y, Carbo A, Hoops S, Hontecillas R, Bassaganya-Riera J. ENISI SDE: A New Web-Based Tool for Modeling Stochastic Processes. IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS. 2015;12(2):289–297. https://doi.org/10.1109/TCBB.2014.2351823.
  • Allison DB, Bassaganya-Riera J, Burlingame B, Brown AW, Coutre J le, Dickson SL, Eden W van, Garssen J, Hontecillas R, Khoo CSH, Knorr D, Kussmann M, Magistretti PJ, Mehta T, Meule A, Rychlik M, Vögele C. Goals in Nutrition Science 2015-2020. Frontiers in nutrition. 2015;2:26. https://doi.org/10.3389/fnut.2015.00026.
  • Carbo A, Hontecillas R, Viladomiu M, Leber A, Hoops S, Bassaganya-Riera J. Modeling the Dynamics of T Helper 17 Induction and Differentiation. MOJ Immunol. 2015;2. https://doi.org/10.15406/moji.2015.02.00038.
  • Lu P, Hontecillas R, Abedi V, Kale S, Leber A, Heltzel C, Langowski M, Godfrey V, Philipson C, Tubau-Juni N, Carbo A, Girardin S, Uren A, Bassaganya-Riera J. Modeling-Enabled Characterization of Novel NLRX1 Ligands. PLoS One. 2015;10(12):e0145420. https://doi.org/10.1371/journal.pone.0145420.
  • Abedi V, Hontecillas R, Carbo A, Philipson C, Hoops S, Bassaganya-Riera J. Multiscale Modeling: Concepts, Technologies, and Use Cases in Immunology. In: Computational Immunology: Models and Tools. 2015.
  • Lemkul JA, Lewis SN, Bassaganya-Riera J, Bevan DR. Phosphorylation of PPAR gamma Affects the Collective Motions of the PPAR gamma-RXR alpha-DNA Complex. PLOS ONE. 2015;10(5). https://doi.org/10.1371/journal.pone.0123984.

2014

  • Bolick DT, Kolling GL, Moore JH, Oliveira LA de, Tung K, Philipson C, Viladomiu M, Hontecillas R, Bassaganya-Riera J, Guerrant RL. Zinc deficiency alters host response and pathogen virulence in a mouse model of enteroaggregative Escherichia coli-induced diarrhea. Gut microbes. 2014;5(5):618–627. https://doi.org/10.4161/19490976.2014.969642.
  • Davis BK, Philipson C, Hontecillas R, Eden K, Bassaganya-Riera J, Allen IC. Emerging Significance of NLRs in Inflammatory Bowel Disease. INFLAMMATORY BOWEL DISEASES. 2014;20(12):2412–2432. https://doi.org/10.1097/MIB.0000000000000151.
  • Hoffman PS, Bruce AM, Olekhnovich I, Warren CA, Burgess SL, Hontecillas R, Viladomiu M, Bassaganya-Riera J, Guerrant RL, Macdonald TL. Preclinical Studies of Amixicile, a Systemic Therapeutic Developed for Treatment of Clostridium difficile Infections That Also Shows Efficacy against Helicobacter pylori. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2014;58(8):4703–4712. https://doi.org/10.1128/AAC.03112-14.
  • Lu P, Hontecillas R, Philipson CW, Bassaganya-Riera J. Lanthionine Synthetase Component C-Like Protein 2: A New Drug Target for Inflammatory Diseases and Diabetes. CURRENT DRUG TARGETS. 2014;15(6):565–572. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=....
  • Kronsteiner B, Bassaganya-Riera J, Philipson N, Hontecillas R. Novel insights on the role of CD8+ T cells and cytotoxic responses during Helicobacter pylori infection. Gut microbes. 2014;5(3):357–362. https://doi.org/10.4161/gmic.28899.
  • Sorrentino D, Nash P, Viladomiu M, Hontecillas R, Bassaganya-Riera J. Stopping Anti-TNF Agents in Patients with Crohn's Disease in Remission: Is It a Feasible Long-term Strategy? INFLAMMATORY BOWEL DISEASES. 2014;20(4):757–766. https://doi.org/10.1097/01.MIB.0000442680.47427.bf.
  • Barbeau WE, Hontecillas R, Horne W, Carbo A, Koch MH, Bassaganya-Riera J. Elevated CD8 T cell responses in type 1 diabetes patients to a 13 amino acid coeliac-active peptide from α-gliadin. Clinical and experimental immunology. 2014;175(2):167–171. https://doi.org/10.1111/cei.12203.
  • Auer K, Trachter R, Bogaerde J Van den, Bassaganya-Riera J, Sorrentino D. Translational research and efficacy of biologics in Crohn's disease: a cautionary tale. EXPERT REVIEW OF CLINICAL IMMUNOLOGY. 2014;10(2):219–229. https://doi.org/10.1586/1744666X.2014.877839.
  • Carbo A, Hontecillas R, Andrew T, Eden K, Mei Y, Hoops S, Bassaganya-Riera J. Computational modeling of heterogeneity and function of CD4+ T cells. Frontiers in cell and developmental biology. 2014;2:31. https://doi.org/10.3389/fcell.2014.00031.
  • Mei Y, Carbo A, Hontecillas R, Hoops S, Liles N, Lu P, Philipson C, Bassaganya-Riera J. ENISI MSM: A Novel Multi-Scale Modeling Platform for Computational Immunology. Presented at the IEEE International Conference on Bioinformatics and Biomedicine (IEEE BIBM), Univ Ulster, Belfast, NORTH IRELAND; 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=....
  • Carbo A, Olivares-Villagomez D, Hontecillas R, Bassaganya-Riera J, Chaturvedi R, Piazuelo MB, Delgado A, Washington MK, Wilson KT, Algood HMS. Systems Modeling of the Role of Interleukin-21 in the Maintenance of Effector CD4(+) T Cell Responses during Chronic Helicobacter pylori Infection. MBIO. 2014;5(4). https://doi.org/10.1128/mBio.01243-14.

2013

  • Carbo A, Bassaganya-Riera J, Pedragosa M, Viladomiu M, Marathe MV, Eubank SG, Wendelsdorf KV, Bisset KR, Hoops S, Deng X, Alam MM, Kronsteiner B, Mei Y, Hontecillas-Magarzo R. Predictive Computational Modeling of the Mucosal Immune Responses during Helicobacter pylori Infection. PLoS One. 2013;8(9):e73365. https://doi.org/10.1371/journal.pone.0073365.
  • Bassaganya-Riera J, Guri AJ, Hontecillas R. Method of synergistically enhancing the therapeutic efficacy and safety of medications through a combination therapy. . 2013. https://patents.google.com/patent/US20100204188A1.
  • Kronsteiner B, Bassaganya-Riera J, Philipson C, Viladomiu M, Carbo A, Pedragosa M, Vento S, Hontecillas R. Helicobacter pylori Infection in a Pig Model Is Dominated by Th1 and Cytotoxic CD8(+) T Cell Responses. INFECTION AND IMMUNITY. 2013;81(10):3803–3813. https://doi.org/10.1128/IAI.00660-13.
  • Philipson CW, Bassaganya-Riera J, Hontecillas R. Animal models of enteroaggregative Escherichia coli infection. Gut microbes. 2013;4(4):281–291. https://doi.org/10.4161/gmic.24826.
  • Hontecillas R, Roberts PC, Carbo A, Vives C, Horne WT, Genis S, Velayudhan B, Bassaganya-Riera J. Dietary abscisic acid ameliorates influenza-virus-associated disease and pulmonary immunopathology through a PPAR gamma-dependent mechanism. JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 2013;24(6):1019–1027. https://doi.org/10.1016/j.jnutbio.2012.07.010.
  • Bolick DT, Roche JK, Hontecillas R, Bassaganya-Riera J, Nataro JP, Guerrant RL. Enteroaggregative Escherichia coli strain in a novel weaned mouse model: exacerbation by malnutrition, biofilm as a virulence factor and treatment by nitazoxanide. JOURNAL OF MEDICAL MICROBIOLOGY. 2013;62:896–905. https://doi.org/10.1099/jmm.0.046300-0.
  • Viladomiu M, Hontecillas R, Yuan L, Lu P, Bassaganya-Riera J. Nutritional protective mechanisms against gut inflammation. JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 2013;24(6):929–939. https://doi.org/10.1016/j.jnutbio.2013.01.006.
  • Olekhnovich IN, Vitko S, Chertihin O, Hontecillas R, Viladomiu M, Bassaganya-Riera J, Hoffman PS. Mutations to Essential Orphan Response Regulator HP1043 of Helicobacter pylori Result in Growth-Stage Regulatory Defects. INFECTION AND IMMUNITY. 2013;81(5):1439–1449. https://doi.org/10.1128/IAI.01193-12.
  • Carbo A, Hontecillas-Magarzo R, Kronsteiner B, Viladomiu M, Pedragosa M, Lu P, Philipson CW, Hoops S, Marathe MV, Eubank SG, Bisset KR, Wendelsdorf KV, Jarrah A, Mei Y, Bassaganya-Riera J. Systems Modeling of Molecular Mechanisms Controlling Cytokine-driven CD4+ T Cell Differentiation and Phenotype Plasticity. PLoS Computational Biology. 2013;9(4):e1003027. http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjourn....
  • Bassaganya-Riera J, Hontecillas R, Isaacs KL. Implementation of integrative approaches to improve the design of Crohn's disease clinical trials. Clinical Nutrition. 2013;32(1):148–149. https://doi.org/10.1016/j.clnu.2012.10.010.
  • Bassaganya-Riera J, Hontecillas R, Isaacs KL. Response to letter to the Editor - Implementation of integrative approaches to improve the design of Crohn's disease clinical trials. CLINICAL NUTRITION. 2013;32(1):148–149. https://doi.org/10.1016/j.clnu.2012.10.010.
  • Mei Y, Carbo A, Hontecillas R, Bassaganya-Riera J. ENISI SDE: A Novel Web-based Stochastic Modeling Tool for Computational Biology. Presented at the IEEE International Conference on Bioinformatics and Biomedicine (IEEE BIBM), Shanghai, PEOPLES R CHINA; 2013. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=....
  • Mei Y, Hontecillas R, Zhang X, Carbo A, Bassaganya-Riera J. Neural Network Models for Classifying Immune Cell Subsets. Presented at the IEEE International Conference on Bioinformatics and Biomedicine (IEEE BIBM), Shanghai, PEOPLES R CHINA; 2013. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=....
  • Bassaganya-Riera J, Kale S, Hontecillas R. Novel orally active ligands of lanthionine synthetase C-like protein 2 ameliorate influenza-related inflammation and immunopathology. 2013. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=....
  • Viladomiu M, Hontecillas R, Lu P, Bassaganya-Riera J. Preventive and Prophylactic Mechanisms of Action of Pomegranate Bioactive Constituents. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. 2013. https://doi.org/10.1155/2013/789764.
  • Philipson CW, Bassaganya-Riera J, Viladomiu M, Pedragosa M, Guerrant RL, Roche JK, Hontecillas R. The Role of Peroxisome Proliferator-Activated Receptor gamma in Immune Responses to Enteroaggregative Escherichia coli Infection. PLOS ONE. 2013;8(2). https://doi.org/10.1371/journal.pone.0057812.

2012

  • Mei Y, Hontecillas-Magarzo R, Zhang X, Bisset KR, Eubank SG, Hoops S, Marathe MV, Bassaganya-Riera J. ENISI Visual, an agent-based simulator for modeling gut immunity. In: Proceedings of the 2012 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE; 2012:1–5. http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=6392624.
  • Bassaganya-Riera J, Hontecillas R, Horne WT, Sandridge M, Herfarth HH, Bloomfeld R, Isaacs KL. Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn's disease. CLINICAL NUTRITION. 2012;31(5):721–727. https://doi.org/10.1016/j.clnu.2012.03.002.
  • Hontecillas R, Bassaganya-Riera J. Expression of PPAR γ in intestinal epithelial cells is dispensable for the prevention of colitis by dietary abscisic acid. e-SPEN journal. 2012;7(5):e189–e195. https://doi.org/10.1016/j.clnme.2012.07.002.
  • Coursodon-Boyiddle CF, Snarrenberg CL, Adkins-Rieck CK, Bassaganya-Riera J, Hontecillas R, Lawrence P, Brenna JT, Jouni ZE, Dvorak B. Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 2012;303(6):G744–G751. https://doi.org/10.1152/ajpgi.00248.2012.
  • Wendelsdorf KV, Alam MM, Bassaganya-Riera J, Bisset KR, Eubank SG, Hontecillas-Magarzo R, Hoops S, Marathe MV. ENteric Immunity SImulator: A tool for in silico study of gastroenteric infections. IEEE Trans Nanobioscience. 2012;11(3):273–288. http://www.ncbi.nlm.nih.gov/pubmed/22987134.
  • Lu P, Hontecillas R, Horne WT, Carbo A, Viladomiu M, Pedragosa M, Bevan DR, Lewis SN, Bassaganya-Riera J. Computational Modeling-Based Discovery of Novel Classes of Anti-Inflammatory Drugs That Target Lanthionine Synthetase C-Like Protein 2. PLOS ONE. 2012;7(4). https://doi.org/10.1371/journal.pone.0034643.
  • Bassaganya-Riera J, Dominguez-Bello MG, Kronsteiner B, Carbo A, Lu P, Viladomiu M, Pedragosa M, Zhang X, Sobral BW, Mane SP, Mohapatra SK, Horne WT, Guri AJ, Groeschl M, Lopez-Velasco G, Hontecillas R. Helicobacter pylori Colonization Ameliorates Glucose Homeostasis in Mice through a PPAR gamma-Dependent Mechanism. PLOS ONE. 2012;7(11). https://doi.org/10.1371/journal.pone.0050069.
  • Bisset KR, Bassaganya-Riera J, Carbo A, Eubank SG, Hontecillas-Magarzo R, Hoops S, Marathe MV, Mei Y, Wendelsdorf KV, Xie D, Yeom J-S, Alam MM. High-Performance Interaction-Based Simulation of Gut Immunopathologies with ENISI. In: Computing & Processing (Hardware/Software). Conference Publications; 2012:48–59. https://doi.org/10.1109/IPDPS.2012.15.
  • Bassaganya-Riera J, Viladomiu M, Pedragosa M, De Simone C, Hontecillas R. Immunoregulatory Mechanisms Underlying Prevention of Colitis-Associated Colorectal Cancer by Probiotic Bacteria. PLOS ONE. 2012;7(4). https://doi.org/10.1371/journal.pone.0034676.
  • Viladomiu M, Hontecillas R, Pedragosa M, Carbo A, Hoops S, Michalak P, Michalak K, Guerrant RL, Roche JK, Warren CA, Bassaganya-Riera J. Modeling the Role of Peroxisome Proliferator-Activated Receptor gamma and MicroRNA-146 in Mucosal Immune Responses to Clostridium difficile. PLOS ONE. 2012;7(10). https://doi.org/10.1371/journal.pone.0047525.
  • Bassaganya-Riera J, Viladomiu M, Pedragosa M, De Simone C, Carbo A, Shaykhutdinov R, Jobin C, Arthur JC, Corl BA, Vogel H, Storr M, Hontecillas R. Probiotic Bacteria Produce Conjugated Linoleic Acid Locally in the Gut That Targets Macrophage PPAR gamma to Suppress Colitis. PLOS ONE. 2012;7(2). https://doi.org/10.1371/journal.pone.0031238.

2011

  • Mazzei JC, Zhou H, Brayfield BP, Hontecillas R, Bassaganya-Riera J, Schmelz EM. Suppression of intestinal inflammation and inflammation-driven colon cancer in mice by dietary sphingomyelin: importance of peroxisome proliferator-activated receptor gamma expression. JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 2011;22(12):1160–1171. https://doi.org/10.1016/j.jnutbio.2010.09.017.
  • Howard MD, Willis L, Wakarchuk W, Michael FS, Cox A, Horne WT, Hontecillas R, Bassaganya-Riera J, Lorenz E, Inzana TJ. Genetics and molecular specificity of sialylation of Histophilus somni lipooligosaccharide (LOS) and the effect of LOS sialylation on Toll-like receptor-4 signaling. VETERINARY MICROBIOLOGY. 2011;153(1-2):163–172. https://doi.org/10.1016/j.vetmic.2011.02.054.
  • Bassaganya-Riera J, Diguardo M, Climent M, Vives C, Carbo A, Jouni ZE, Einerhand AW, O'Shea M, Hontecillas R. Activation of PPARgamma and delta by dietary punicic acid ameliorates intestinal inflammation in mice. British Journal of Nutrition. 2011:1–9. https://doi.org/10.1017/S0007114511001188.
  • Hontecillas-Magarzo R, Horne WT, Climent M, Guri AJ, Evans C, Zhang Y, Sobral BW, Bassaganya-Riera J. Immunoregulatory mechanisms of macrophage PPAR gamma in mice with experimental inflammatory bowel disease. Mucosal Immunology. 2011;4(3):304–314. https://doi.org/10.1038/mi.2010.75.
  • Guri AJ, Bassaganya-Riera J. Systemic effects of white adipose tissue dysregulation and obesity-related inflammation. Obesity. 2011;19. https://doi.org/10.1038/oby.2010.230.
  • Bassaganya-Riera J, DiGuardo M, Climent M, Vives C, Carbo A, Jouni ZE, Einerhand AWC, O'Shea M, Hontecillas R. Activation of PPAR gamma and delta by dietary punicic acid ameliorates intestinal inflammation in mice. BRITISH JOURNAL OF NUTRITION. 2011;106(6):878–886. https://doi.org/10.1017/S0007114511001188.
  • Guri AJ, Evans NP, Hontecillas R, Bassaganya-Riera J. T cell PPAR gamma is required for the anti-inflammatory efficacy of abscisic acid against experimental IBD. JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 2011;22(9):812–819. https://doi.org/10.1016/j.jnutbio.2010.06.011.
  • Bassaganya-Riera J, DiGuardo M, Viladomiu M, Horna A de, Sanchez S, Einerhand AWC, Sanders L, Hontecillas R. Soluble Fibers and Resistant Starch Ameliorate Disease Activity in Interleukin-10-Deficient Mice with Inflammatory Bowel Disease. JOURNAL OF NUTRITION. 2011;141(7):1318–1325. https://doi.org/10.3945/jn.111.139022.
  • Vroegrijk IOCM, Diepen JA van, Berg S van den, Westbroek I, Keizer H, Gambelli L, Hontecillas R, Bassaganya-Riera J, Zondag GCM, Romijn JA, Havekes LM, Voshol PJ. Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice. FOOD AND CHEMICAL TOXICOLOGY. 2011;49(6):1426–1430. https://doi.org/10.1016/j.fct.2011.03.037.
  • Bassaganya-Riera J, Guri AJ, Lu P, Climent M, Carbo A, Sobral BW, Horne WT, Lewis SN, Bevan DR, Hontecillas R. Abscisic Acid Regulates Inflammation via Ligand-binding Domain-independent Activation of Peroxisome Proliferator-activated Receptor gamma. JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(4):2504–2516. https://doi.org/10.1074/jbc.M110.160077.
  • Lewis SN, Brannan L, Guri AJ, Lu P, Hontecillas R, Bassaganya-Riera J, Bevan DR. Dietary alpha-Eleostearic Acid Ameliorates Experimental Inflammatory Bowel Disease in Mice by Activating Peroxisome Proliferator-Activated Receptor-gamma. PLOS ONE. 2011;6(8). https://doi.org/10.1371/journal.pone.0024031.

2010

  • Bassaganya-Riera J, Hontecillas R. Conjugated linoleic acid and n-3 PUFA in inflammatory bowel disease. Clinical Nutrition, Metabolic Care. 2010;13:569–573. https://doi.org/10.1097/MCO.0b013e32833b648e.
  • Mane SP, Dominguez-Bello MG, Blaser MJ, Sobral BW, Hontecillas R, Skoneczka J, Mohapatra SK, Crasta OR, Evans C, Modise T, Shallom S, Shukla M, Varon C, Megraud F, Maldonado-Contreras AL, Williams KP, Bassaganya-Riera J. Host-Interactive Genes in Amerindian Helicobacter pylori Diverge from Their Old World Homologs and Mediate Inflammatory Responses. JOURNAL OF BACTERIOLOGY. 2010;192(12):3078–3092. https://doi.org/10.1128/JB.00063-10.
  • Bassaganya-Riera J, Guir AJ, Hontecillas R. Method of using ABA for preventing and treating gut inflammatory disorders. . 2010. https://patents.google.com/patent/US8367727B2.
  • Guri AJ, Misyak SA, Hontecillas-Magarzo R, Hasty A, Liu D, Si H, Bassaganya-Riera J. Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4+ T cell recruitment into the aortic wall. The Journal of Nutritional Biochemistry. 2010;21(12):1178–1185. http://www.sciencedirect.com/science/article/B6T8P-4Y7NDK4-4/2/e....
  • Guri AJ, Hontecillas-Magarzo R, Bassaganya-Riera J. Abscisic acid ameliorates experimental IBD by downregulating cellular adhesion molecule expression and suppressing immune cell infiltration. Clinical Nutrition. 2010;29:824–831. https://doi.org/10.1016/j.clnu.2010.02.009.
  • Guri AJ, Hontecillas-Magarzo R, Bassaganya-Riera J. Abscisic acid synergizes with rosiglitazone to improve glucose tolerance and down-modulate macrophage accumulation in adipose tissue: Possible action of the cAMP/PKA/PPAR [gamma] axis. Clinical Nutrition. 2010;29(5):646–653. http://www.sciencedirect.com/science/article/B6WCM-4YJ140J-1/2/0....
  • Evans NP, Misyak SA, Schmelz EM, Guri AJ, Hontecillas-Magarzo R, Bassaganya-Riera J. Conjugated Linoleic Acid Ameliorates Inflammation-Induced Colorectal Cancer in Mice through Activation of PPAR gamma. The Journal of Nutrition. 2010;140(3):515–521. http://jn.nutrition.org/content/140/3/515.abstract.
  • Chafin C, Muse S, Hontecillas R, Bassaganya-Riera J, Caudell DL, Shimp SK, Rylander MN, Zhang J, Li L, Reilly CM. Deletion of PPAR-γ in immune cells enhances susceptibility to antiglomerular basement membrane disease. Journal of inflammation research. 2010;3:127–134. https://doi.org/10.2147/jir.s13394.
  • Bassaganya-Riera J, Hontecillas-Magarzo R. Dietary conjugated linoleic acid and n-3 polyunsaturated fatty acids in inflammatory bowel disease. Current Opinion in Clinical Nutrition and Metabolic Care. 2010;13(5):569–573. http://ovidsp.tx.ovid.com/sp-3.8.0b/ovidweb.cgi?&S=MONIFPEKJPDDA....|1|sl_10.
  • Guill S, Hargens T, Nickols-Richardson S, Bassaganya-Riera J, Miller L, Zedalis D, Gregg J, Gwazdauskas F, Herbert W. Early evidence of increased risk for metabolic syndrome in young men with latent obstructive sleep apnea. Metab Syndr Relat Disord. 2010;8(1):33–38. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=Pu....
  • Jesmin MSMR, Jamil H, Hontecillas-Magarzo R, Bassaganya-Riera J. Gene regulatory network reveals oxidative stress as the underlying molecular mechanism of type 2 diabetes and hypertension. BMC Medical Genomics. 2010;3. https://doi.org/10.1186/1755-8794-3-45.
  • Fu Z, Zhang W, Zhen W, Lum H, Nadler J, Bassaganya-Riera J, Jia Z, Wang Y, Misra H, Liu D. Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice. Endocrinology. 2010;151(7):3026–3037. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=Pu....
  • Evans NP, Call JA, Bassaganya-Riera J, Robertson JL, Grange RW. Green tea extract decreases muscle pathology and NF-kappaB immunostaining in regenerating muscle fibers of mdx mice. Clin Nutr. 2010;29(3):391–398. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=Pu....
  • Mohapatra SK, Guri AJ, Climent M, Vives C, Carbo A, Horne WT, Hontecillas R, Bassaganya-Riera J. Immunoregulatory Actions of Epithelial Cell PPAR gamma at the Colonic Mucosa of Mice with Experimental Inflammatory Bowel Disease. PLOS ONE. 2010;5(4). https://doi.org/10.1371/journal.pone.0010215.
  • Bassaganya-Riera J, Skoneczka J, Kingston DGJ, Krishnan A, Misyak SA, Guri AJ, Pereira A, Carter AB, Minorsky P, Tumarkin R, Hontecillas-Magarzo R. Mechanisms of Action and Medicinal Applications of Abscisic Acid. Current Medicinal Chemistry. 2010;17:467–478. http://www.ingentaconnect.com/content/ben/cmc/2010/00000017/0000....
  • Wendelsdorf KV, Bassaganya-Riera J, Hontecillas R, Eubank SG. Model of colonic inflammation: Immune modulatory mechanisms in inflammatory bowel disease. Journal of Theoretical Biology. 2010;264(4):1225–1239. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=Pu....
  • Mohapatra SK, Cole LE, Evans C, Sobral BW, Bassaganya-Riera J, Hontecillas-Magarzo R, Vogel SN, Crasta OR. Modulation of hepatic PPAR expression during Ft LVS LPS-induced protection from Francisella tularensis LVS infection. BMC infectious diseases. 2010;10(1):10. http://www.biomedcentral.com/1471-2334/10/10.
  • Lu P, Bevan DR, Lewis SN, Hontecillas-Magarzo R, Bassaganya-Riera J. Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics. Journal of Molecular Modeling. 2010:1–11.
  • Bassaganya-Riera J, Song R, Roberts PC, Hontecillas-Magarzo R. PPAR-gamma activation as an anti-inflammatory therapy for respiratory virus infections. Viral Immunol. 2010;23(4):343–352. http://www.ncbi.nlm.nih.gov/pubmed/20712478.
  • Guri AJ, Mohapatra SK, Horne WT, Hontecillas R, Bassaganya-Riera J. The Role of T cell PPAR gamma in mice with experimental inflammatory bowel disease. BMC GASTROENTEROLOGY. 2010;10(1):60. https://doi.org/10.1186/1471-230X-10-60.
  • Dyer MD, Neff C, Dufford M, Rivera CG, Shattuck D, Bassaganya-Riera J, Murali TM, Sobral BW. The human-bacterial pathogen protein interaction networks of Bacillus anthracis, Francisella tularensis, and Yersinia pestis. PLoS One. 2010;5(8):e12089. http://www.ncbi.nlm.nih.gov/pubmed/20711500.
  • Bassaganya-Riera J, Guri AJ, Hontecillas-Magarzo R. Treatment of obesity-related complications with novel classes of naturally occurring PPAR agonists. Journal of Obesity. 2010;2011. http://www.hindawi.com/journals/jobes/2011/897894/.
  • Lewis SN, Bassaganya-Riera J, Bevan D. Virtual Screening as a Technique for PPAR Modulator Discovery. PPAR Res. 2010;2010:861238. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=Pu....

2009

  • Evans NP, Misyak SA, Robertson JL, Bassaganya-Riera J, Grange RW. Immune-Mediated Mechanisms Potentially Regulate the Disease Time-Course of Duchenne Muscular Dystrophy and Provide Targets for Therapeutic Intervention. PM&R. 2009;1(8):755–768. https://doi.org/10.1016/j.pmrj.2009.04.010.
  • Evans NP, Misyak SA, Robertson JL, Bassaganya-Riera J, Grange RW. Dysregulated Intracellular Signaling and Inflammatory Gene Expression During Initial Disease Onset in Duchenne Muscular Dystrophy. AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION. 2009;88(6):502–522. https://doi.org/10.1097/PHM.0b013e3181a5a24f.
  • Meerts IATM, Verspeek-Rip CM, Buskens CAF, Keizer HG, Bassaganya-Riera J, Jouni ZE, Huygevoort AHBM van, Otterdijk FM van, Waart EJ van de. Toxicological evaluation of pomegranate seed oil. FOOD AND CHEMICAL TOXICOLOGY. 2009;47(6):1085–1092. https://doi.org/10.1016/j.fct.2009.01.031.
  • Hontecillas R, O'Shea M, Einerhand A, Diguardo M, Bassaganya-Riera J. Activation of PPAR gamma and alpha by Punicic Acid Ameliorates Glucose Tolerance and Suppresses Obesity-Related Inflammation. JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION. 2009;28(2):184–195. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=....
  • Bassaganya-Riera J, Ferrer G, Casagran O, Sanchez S, Horna A de, Duran E, Orpi M, Guri AJ, Hontecillas R. F4/80hiCCR2hi macrophage infiltration into the intra-abdominal fat worsens the severity of experimental IBD in obese mice with DSS colitis. e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism. 2009;4(2):e90–e97. https://doi.org/10.1016/j.eclnm.2008.11.005.
  • Sassano G, Sanderson P, Franx J, Groot P, Straalen J van, Bassaganya-Riera J. Analysis of pomegranate seed oil for the presence of jacaric acid. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE. 2009;89(6):1046–1052. https://doi.org/10.1002/jsfa.3552.
  • Carter AB, Misyak SA, Hontecillas R, Bassaganya-Riera J. Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPAR gamma. PPAR RESEARCH. 2009. https://doi.org/10.1155/2009/498352.
  • Bassaganya-Riera J, Misyak S, Guri AJ, Hontecillas R. PPAR gamma is highly expressed in F4/80(hi) adipose tissue macrophages and dampens adipose-tissue inflammation. CELLULAR IMMUNOLOGY. 2009;258(2):138–146. https://doi.org/10.1016/j.cellimm.2009.04.003.

2008

  • Hontecillas R, Diguardo M, Duran E, Orpi M, Bassaganya-Riera J. Catalpic acid decreases abdominal fat deposition, improves glucose homeostasis and upregulates PPAR alpha expression in adipose tissue. CLINICAL NUTRITION. 2008;27(5):764–772. https://doi.org/10.1016/j.clnu.2008.07.007.
  • Guri AJ, Hontecillas R, Ferrer G, Casagran O, Wankhade U, Noble AM, Eizirik DL, Ortis F, Cnop M, Liu D, Si H, Bassaganya-Riera J. Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue. JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 2008;19(4):216–228. https://doi.org/10.1016/j.jnutbio.2007.02.010.
  • Thakare K, Shi W, Barbeau WE, Bassaganya-Riera J, Hontecillas R, Scott F. Investigation of chloroform-methanol soluble wheat proteins and sphingolipids as potential dietary triggers of diabetes in BBdp rats. FOOD AND AGRICULTURAL IMMUNOLOGY. 2008;19(1):25–48. https://doi.org/10.1080/09540100801915345.
  • Guri AJ, Hontecillas R, Bassaganya-Riera J. Dietary Modulators of Peroxisome Proliferator-Activated Receptors: Implications for the Prevention and Treatment of Metabolic Syndrome. JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS. 2008;1(3):126–135. https://doi.org/10.1159/000112460.