The NIMML uses innovation to tackle global challenges in infectious, immune-mediated and chronic inflammatory disease research. We combine computational approaches with pre-clinical and clinical experimentation to transition new biological knowledge into disruptive therapeutics for human diseases.

Highlights

People

Principal Investigators

Josep Bassaganya-Riera

Director and Research Professor, NIMML

Raquel Hontecillas-Magarzo

Research Associate Professor

Shiv Kale

Research Scientist

Publications

2016


Coutermarch-Ott S, Simmons A, Capria V, et al. NLRX1 Suppresses Tumorigenesis and Attenuates Histiocytic Sarcoma through the Negative Regulation of NF-κB Signaling. Oncotarget. 2016;In Press.  

Leber A, Abedi V, Hontecillas R, et al. Bistability analyses of CD4+ T follicular helper and regulatory cells during Helicobacter pylori infection. Journal of Theoretical Biology. 2016;In Press.  

Verma M, Hontecillas R, Abedi V, et al. Modeling-Enabled Systems Nutritional Immunology. Frontiers in Nutrition, section Nutritional Immunology. 2016;In Press.  

2015


Abedi V, Hontecillas R, Carbo A, Philipson C, Hoops S, Bassaganya-Riera J. Multiscale Modeling: Concepts, Technologies, and Use Cases in Immunology. In: Computational Immunology: Models and Tools. Vol. In Press.; 2015.  

Abedi V, Hontecillas R, Hoops S, et al. ENISI Multiscale modeling of mucosal immune responses driven by high performance computing. Washington, DC, USA; 2015. IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2015).  

Abedi V, Hoops S, Hontecillas R, et al. Modeling exercises. In: Computational Immunology: Models and Tools. Vol. In Press.; 2015.  

Abedi V, Lu P, Hontecillas R, et al. Phase III Placebo-Controlled, Randomized Clinical Trial with Synthetic Crohn's disease Patients to Evaluate Treatment Response. In: Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology ? Systems & Applications. Vol. In Press. Elsevier/MK; 2015.  

Alam M, Abedi V, Bassaganya-Riera J, et al. Agent-Based Modeling and High Performance Computing. In: Computational Immunology: Models and Tools. Vol. In Press.; 2015.  

Alam M, Deng X, Philipson C, et al. Sensitivity analysis of an Enteric Immunity Simulator (ENISI)-based model of immune responses to Helicobacter pylori infection. Plos. 2015;10:e0136139.  

Allison DB, Bassaganya-Riera J, Burlingame B, et al. Goals in Nutrition Science 2015-2020. Front Nutr. 2015;2:26.  

Bassaganya-Riera J, Hontecillas R. Introduction to Computational Immunology. In: Computational Immunology: Models and Tools. Vol. In Press.; 2015.  

Bassaganya-Riera J, Hontecillas R, Abedi V, Carbo A, Philipson C, Hoops S. Computational Modeling. In: Computational Immunology: Models and Tools. Vol. In Press.; 2015.  

Carbo A, Hontecillas R, Viladomiu M, Leber A, Hoops S, Bassaganya-Riera J. Modeling the Dynamics of T Helper 17 Induction and Differentiation. MOJ Immunol. 2015;2.  

Hontecillas R, Bassaganya-Riera J, Philipson C, et al. Use of Computational Modeling in Immunological Research. In: Computational Immunology: Models and Tools. Vol. In Press.; 2015.  

Hoops S, Hontecillas R, Abedi V, et al. Ordinary Differential Equations (ODE) based Modeling. In: Computational Immunology: Models and Tools. Vol. In Press.; 2015.  

Hoops S, Sobral BW, Michalak P, et al. Immunoinformatics cybernfrastructure for modeling and analytics. In: Computational Immunology: Models and Tools. Vol. In Press.; 2015.  

Kronsteiner B, Bassaganya-Riera J, Philipson C, et al. Systems-wide analyses of mucosal immune responses to Helicobacter pylori at the interface between pathogenicity and symbiosis. Gut Microbes. 2015;In Press.  

Leber A, Viladomiu M, Hontecillas R, et al. Systems Modeling of Interactions between Mucosal Immunity and the Gut Microbiome during Clostridium difficile Infection. PloS one. 2015;10:e0134849.  

Lemkul JA, Lewis SN, Bassaganya-Riera J, Bevan DR. Phosphorylation of PPARγ Affects the Collective Motions of the PPARγ-RXRα-DNA Complex. PloS one. 2015;10.  

Lewis SN, Garcia Z, Hontecillas R, Bassaganya-Riera J, Bevan DR. Pharmacophore modeling improves virtual screening for novel peroxisome proliferator-activated receptor-gamma ligands. J Comput Aided Mol Des. 2015;29:421–439.  

Lu P, Abedi V, Mei Y, et al. Supervised learning methods in modeling of CD4+ T cell heterogeneity. BioData Min. 2015;8:27.  

Lu P, Abedi V, Mei Y, et al. Supervised Learning with Artificial Neural Network in Modeling of Cell Differentiation Process. In: Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology. Burlington, Massachusetts: Morgan Kaufmann; 2015.  

Lu P, Hontecillas R, Abedi V, et al. Modeling-Enabled Characterization of Novel NLRX1 ligands. Plos One. 2015;In Press.  

Mei Y, Abedi V, Carbo A, et al. Multiscale modeling of mucosal immune responses. BMC Bioinformatics. 2015;16:S2.  

Mei Y, Carbo A, Hoops S, Hontecillas R, Bassaganya-Riera J. ENISI SDE: A New Web-Based Tool for Modeling Stochastic Processes. Computational Biology and Bioinformatics, IEEE/ACM Transactions on. 2015;12:289–297.  

Michalak P, Sobral BW, Abedi V, et al. From Big Data Analytics and Network Inference to Systems Modeling. In: Computational Immunology: Models and Tools. Vol. In Press.; 2015.  

Philipson CW, Bassaganya-Riera J, Viladomiu M, et al. Modeling the Regulatory Mechanisms by Which NLRX1 Modulates Innate Immune Responses to Helicobacter pylori Infection. PLoS One. 2015;10:e0137839.  

Viladomiu M, Hontecillas R, Bassaganya-Riera J. Modulation of inflammation and immunity by dietary conjugated linoleic acid. Eur J Pharmacol. 2015.  

2014


Auer K, Trachter R, Van den Bogaerde J, Bassaganya-Riera J, Sorrentino D. Translational research and efficacy of biologics in Crohn's disease: a cautionary tale. Expert Rev Clin Immunol. 2014;10:219–229.  http://www.ncbi.nlm.nih.gov/pubmed/24410538

Barbeau WE, Hontecillas R, Horne W, Carbo A, Koch MH, Bassaganya-Riera J. Elevated CD8 T cell responses in type 1 diabetes patients to a 13 amino acid coeliac-active peptide from alpha-gliadin. Clin Exp Immunol. 2014;175:167–171.  http://www.ncbi.nlm.nih.gov/pubmed/24016298

Barbeau WE, Hontecillas R, Horne W, Carbo A, Koch MH, Bassaganya-Riera J. Elevated CD8 T cell responses in type 1 diabetes patients to a 13 amino acid coeliac-active peptide from α-gliadin. Clinical & Experimental Immunology. 2014;175:167–171.  http://dx.doi.org/10.1111%2Fcei.12203

Bolick DT, Kolling GL, Moore JH, et al. Zinc Deficiency Alters Host Response and Pathogen Virulence in a Mouse Model of Enteroaggregative Escherichia coli-Induced Diarrhea. Gut microbes. 2014;5:618–627.  http://www.tandfonline.com/doi/abs/10.4161/19490976.2014.969642#.VK_zhYeMHx4

Carbo A, Hontecillas R, Andrew T, et al. Computational modeling of heterogeneity and function of CD4+ T cells. Frontiers in Cell and Developmental Biology. Systems Biology. 2014;In Press.  

Carbo A, Hontecillas R, Andrew T, et al. Computational modeling of heterogeneity and function of CD4+ T cells. Front Cell Dev Biol. 2014;2:31.  

Carbo A, Olivares-Villagomez D, Hontecillas R, et al. Systems modeling of the role of interleukin-21 in the maintenance of effector CD4+ T cell responses during chronic Helicobacter pylori infection. MBio. 2014;5:e01243–14.  

Carbo A, Olivares-Villagomez D, Hontecillas R, et al. Systems modeling of the role of IL-21 in the maintenance of effector responses during chronic Helicobacter pylori infection. mBio. 2014;In Press.  

Davis BK, Philipson C, Hontecillas R, Eden K, Bassaganya-Riera J, Allen IC. The emerging significance of NLRs in inflammatory bowel disease. Inflammatory Bowel Diseases. 2014;In Press.  

Davis BK, Philipson C, Hontecillas R, Eden K, Bassaganya-Riera J, Allen IC. Emerging significance of NLRs in inflammatory bowel disease. Inflamm Bowel Dis. 2014;20:2412–2432.  

Hoffman PS, Marshall AM, Olekhnovich I, et al. Preclinical Studies of Amixicile: A Systemic Therapeutic Developed for Treatment of Clostridium difficile Infections also shows Efficacy against Helicobacter pylori. Antimicrobial Agents and Chemotherapy. 2014:Aac. 03112–14.  

Kronsteiner B, Bassaganya-Riera J, Philipson N, Hontecillas R. Novel insights on the role of CD8+ T cells and cytotoxic responses during Helicobacter pylori infection. Gut microbes. 2014;5:0–1.  

Lu P, Hontecillas R, Philipson CW, Bassaganya-Riera J. Lanthionine Synthetase Component C-like Protein 2: A New Drug Target for Inflammatory Diseases and Diabetes. Curr Drug Targets. 2014.  http://www.ncbi.nlm.nih.gov/pubmed/24628287

Mei Y, Carbo A, Hontecillas R, et al. ENISI MSM: A novel multiscale modeling platform for computational immunology. Bibm. 2014;2.  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207042/

Mei Y, Carbo A, Hoops S, Hontecillas R, Bassaganya-Riera J. ENISI SDE: A web-based tool for modeling stochastic processes. Transactions of Computational Biology and Bioinformatics. 2014;In Press.  

Sorrentino D, Nash P, Viladomiu M, Hontecillas R, Bassaganya-Riera J. Stopping Anti-TNF Agents in Patients with Crohn's Disease in Remission: Is It a Feasible Long-term Strategy? Inflamm Bowel Dis. 2014;20:757–766.  http://www.ncbi.nlm.nih.gov/pubmed/24572206

2013


Barbeau WE, Hontecillas R, Carbo A, Horne WT, Koch MH, Bassaganya-Riera J. Elevated CD8+ T cell responses in type 1 diabetes patients to a 13 amino acid celiac-active peptide from alpha-gliadin. Clinical and Experimental Immunology. 2013;In Press.  

Bassaganya-Riera J, Hontecillas R, Isaacs KL. Response to letter to the Editor ? Implementation of integrative approaches to improve the design of Crohn's disease clinical trials. Clinical Nutrition. 2013;32:148–149.  http://www.sciencedirect.com/science/article/pii/S0261561412002257

Bolick DT, Roche JK, Hontecillas R, Bassaganya-Riera J, Nataro JP, Guerrant RL. Enteroaggregative Escherichia coli strain in a novel weaned mouse model: exacerbation by malnutrition, biofilm as a virulence factor and treatment by nitazoxanide. Journal of Medical Microbiology. 2013;62:896–905.  http://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.046300-0

Carbo A, Bassaganya-Riera J, Pedragosa M, et al. Predictive Computational Modeling of the Mucosal Immune Responses during Helicobacter pylori Infection. PLoS ONE. 2013;8:e73365.  http://dx.doi.org/10.1371%2Fjournal.pone.0073365

Carbo A, Hontecillas R, Kronsteiner B, et al. Systems Modeling of Molecular Mechanisms Controlling Cytokine-driven CD4+ T Cell Differentiation and Phenotype Plasticity. PLoS Comput Biol. 2013;9:e1003027.  http://dx.doi.org/10.1371%2Fjournal.pcbi.1003027

Hontecillas R, Roberts PC, Carbo A, Horne WT, Velayudhan B, Bassaganya-Riera J. Abscisic acid ameliorates influenza virus-related pulmonary pathology and down-regulates MCP-1 through a PPAR g-dependent mechanism. Journal of Nutritional Biochemistry. 2013;6(24):1019–27.  http://www.ncbi.nlm.nih.gov/pubmed/22995385

Kronsteiner B, Bassaganya-Riera J, Philipson C, et al. Helicobacter pylori infection in a pig model is dominated by Th1 and cytotoxic CD8+ T cell responses. Infect Immun. 2013;81:3803–3813.  http://www.ncbi.nlm.nih.gov/pubmed/23897614

Mei Y, Carbo A, Hontecillas R, Bassaganya-Riera J. ENISI SDE: A Novel Web-based Stochastic Modeling Tool for Computational Biology. Bibm. 2013;In Press.  

Mei Y, Hontecillas R, Xiaoying Z, Carbo A, Bassaganya-Riera J. Neural network models for classifying immune cell subsets.; 2013:5–11. Bioinformatics and Biomedicine (BIBM), 2013 IEEE International Conference on.  

Mei Y, Hontecillas R, Zhang X, Carbo A, Bassaganya-Riera J. Neural Network Models for Classifying Immune Cell Subsets. Bibm. 2013;In Press.  

Olekhnovich IN, Vitko S, Chertihin O, et al. Mutations to Essential Orphan Response Regulator HP1043 of Helicobacter pylori Result in Growth-Stage Regulatory Defects. Infection and Immunity. 2013;81:1439–1449.  http://iai.asm.org/content/81/5/1439.abstract

Philipson CW, Bassaganya-Riera J, Hontecillas R. Animal models of enteroaggregative Escherichia coli infection. Gut microbes. 2013;4:281–291.  

Philipson CW, Bassaganya-Riera J, Viladomiu M, et al. The Role of Peroxisome Proliferator-Activated Receptor γ in Immune Responses to Enteroaggregative Escherichia coli Infection. PloS one. 2013;8:e57812.  

Philipson CW, Bassaganya-Riera J, Viladomiu M, et al. The Role of Peroxisome Proliferator-Activated Receptor γ in Immune Responses to Enteroaggregative Escherichia coli Infection. PLoS ONE. 2013;8:e57812.  http://dx.doi.org/10.1371%2Fjournal.pone.0057812

Viladomiu M. H R. Yuan L. Lu P. Bassaganya-Riera J. Nutritional protective mechanisms against gut inflammation. Journal of Nutritional Biochemistry,. 2013;6(24):929–39.  http://www.sciencedirect.com/science/article/pii/S0955286313000302

Viladomiu M Hontecillas R. Lu P. Bassaganya-Riera J. Preventive and prophylactic mechanisms of action of pomegranate bioactive constituents. Evidence-based Complementary and Alternative Medicine.. 2013;2013:789764.  http://dx.doi.org/10.1155%2F2013%2F789764

Viladomiu M, Hontecillas R, Yuan L, Lu P, Bassaganya-Riera J. Nutritional protective mechanisms against gut inflammation. The Journal of Nutritional Biochemistry. 2013;24:929–939.  http://www.sciencedirect.com/science/article/pii/S0955286313000302

Yongguo M, Carbo A, Hontecillas R, Bassaganya-Riera J. ENISI SDE: A novel web-based stochastic modeling tool for computational biology.; 2013:392–397. Bioinformatics and Biomedicine (BIBM), 2013 IEEE International Conference on.  

2012


Bassaganya-Riera J, Dominguez-Bello MG, Kronsteiner B, et al. Helicobacter pylori Colonization Ameliorates Glucose Homeostasis in Mice through a PPAR γ-Dependent Mechanism. PLoS ONE. 2012;7:e50069.  http://dx.doi.org/10.1371%2Fjournal.pone.0050069

Bassaganya-Riera J, Hontecillas R, Horne WT, et al. Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn's disease. Clin Nutr. 2012.  http://www.ncbi.nlm.nih.gov/pubmed/22521469

Bassaganya-Riera J, Hontecillas R, Isaacs KL. Implementation of integrative approaches to improve the design of Crohn's disease clinical trials. Clinical Nutrition. 2012;32:148–149.  http://dx.doi.org/10.1016%2Fj.clnu.2012.10.010

Bassaganya-Riera J, Viladomiu M, Pedragosa M, et al. Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR gamma to suppress colitis. PLoS One. 2012;7:e31238.  http://www.ncbi.nlm.nih.gov/pubmed/22363592

Bassaganya-Riera J, Viladomiu M, Pedragosa M, De Simone C, Hontecillas R. Immunoregulatory mechanisms underlying prevention of colitis-associated colorectal cancer by probiotic bacteria. PLoS One. 2012;7:e34676.  http://www.ncbi.nlm.nih.gov/pubmed/22511958

Bisset K, Alam MM, Bassaganya-Riera J, et al. High-Performance Interaction-Based Simulation of Gut Immunopathologies with ENteric Immunity Simulator (ENISI).; 2012:48–59. Parallel & Distributed Processing Symposium (IPDPS), 2012 IEEE 26th International.  

Bisset K, Bassaganya-Riera J, Carbo A, et al. High-performance interaction-based simulation of gut immunopathologies with ENISI. Shanghai, China; 2012. Ieee Ipdps.  

Coursodon-Boyiddle C, Snarrenberg C, Adkins-Rieck C, et al. Pomegranate seed oil reduces damage in a rat model of necrotizing enterocolitis. American Journal of Physiology ? Gastrointestinal and Liver Physiology. 2012;In Press.  

Coursodon-Boyiddle CF, Snarrenberg CL, Adkins-Rieck CK, et al. Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis. American Journal of Physiology – Gastrointestinal and Liver Physiology. 2012;303:G744–G751.  http://ajpgi.physiology.org/content/303/6/G744.abstract

Hontecillas R, Bassaganya-Riera J. Expression of PPAR γ in intestinal epithelial cells is dispensable for the prevention of colitis by dietary abscisic acid. e-SPEN Journal. 2012;7:e189–e195.  http://www.sciencedirect.com/science/article/pii/S2212826312000383

Hontecillas R, Bassaganya-Riera J. Expression of PPAR gamma in intestinal epithelial cell is dispensable for the prevention of colitis by dietary abscisic acid. e-SPEN Journal. 2012;7:e189–e195.  

Kale SD. Oomycete and fungal effector entry, a microbial Trojan horse. New Phytol. 2012;193:874–881.  http://www.ncbi.nlm.nih.gov/pubmed/22403824

Kale SD, Tyler BM. Identification of lipid-binding effectors. Methods Mol Biol. 2012;835:393–414.  http://www.ncbi.nlm.nih.gov/pubmed/22183667

Lu P, Hontecillas R, Horne WT, et al. Computational modeling-based discovery of novel classes of anti-inflammatory drugs that target lanthionine synthetase C-like protein 2. PLoS One. 2012;7:e34643.  http://www.ncbi.nlm.nih.gov/pubmed/22509338

Mei Y, Hontecillas R, Zhang X, et al. ENISI Visual, an agent-based simulator for modeling gut immunity. Philadelphia, PA; 2012. IEEE International Conference on Bioinformatics and Biomedicine (BIBM) In Press.  

Sun F, Kale SD, Azurmendi HF, Li D, Tyler BM, Capelluto DG. Structural Basis for Interactions of the Phytophthora sojae RxLR Effector Avh5 with Phosphatidylinositol 3-phosphate and for Host Cell Entry. Mol Plant Microbe Interact. 2012.  http://www.ncbi.nlm.nih.gov/pubmed/23075041

Viladomiu M, Hontecillas R, Pedragosa M, et al. Modeling the Role of Peroxisome Proliferator-Activated Receptor γ and MicroRNA-146 in Mucosal Immune Responses to Clostridium difficile. PloS one. 2012;7:e47525.  

Wendelsdorf KV, Alam M, Bassaganya-Riera J, et al. ENteric Immunity SImulator: A Tool for In Silico Study of Gastroenteric Infections. IEEE Trans Nanobioscience. 2012;11:273–288.  http://www.ncbi.nlm.nih.gov/pubmed/22987134

2011


Bassaganya-Riera J, Diguardo M, Climent M, et al. Activation of PPARgamma and delta by dietary punicic acid ameliorates intestinal inflammation in mice. Br J Nutr. 2011;106:878–886.  http://www.ncbi.nlm.nih.gov/pubmed/21736821

Bassaganya-Riera J, DiGuardo M, Viladomiu M, et al. Soluble fibers and resistant starch ameliorate disease activity in interleukin-10-deficient mice with inflammatory bowel disease. J Nutr. 2011;141:1318–1325.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21562241

Bassaganya-Riera J, DiGuardo M, Viladomiu M, et al. Soluble Fibers and Resistant Starch Ameliorate Disease Activity in Interleukin-10?Deficient Mice with Inflammatory Bowel Disease. The Journal of Nutrition. 2011;141:1318–1325.  http://jn.nutrition.org/content/141/7/1318.abstract

Bassaganya-Riera J, Guri AJ, Hontecillas R. Treatment of Obesity-Related Complications with Novel Classes of Naturally Occurring PPAR Agonists. J Obes. 2011;2011:897894.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21253508

Bassaganya-Riera J, Guri AJ, Lu P, et al. Abscisic Acid Regulates Inflammation via Ligand-binding Domain-independent Activation of Peroxisome Proliferator-activated Receptor γ. Journal of Biological Chemistry. 2011;286:2504–2516.  http://www.jbc.org/content/286/4/2504.abstract

Bassaganya-Riera J, Guri AJ, Lu P, et al. Abscisic acid regulates inflammation via ligand-binding domain-independent activation of peroxisome proliferator-activated receptor gamma. J Biol Chem. 2011;286:2504–2516.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21088297

Dong S, Yu D, Cui L, et al. Sequence variants of the Phytophthora sojae RxLR effector Avr3a/5 are differentially recognized by Rps3a and Rps5. PLoS ONE. 2011.  

Guri AJ, Bassaganya-Riera J. Systemic Effects of White Adipose Tissue Dysregulation and Obesity-Related Inflammation. Obesity. 2011;19:689–700.  http://dx.doi.org/10.1038%2Foby.2010.230

Guri AJ, Evans NP, Hontecillas R, Bassaganya-Riera J. T cell PPARγ is required for the anti-inflammatory efficacy of abscisic acid against experimental IBD. The Journal of Nutritional Biochemistry. 2011;22:812–819.  http://www.sciencedirect.com/science/article/pii/S0955286310001701

Hontecillas R, Horne WT, Climent M, et al. Immunoregulatory mechanisms of macrophage PPAR-γ in mice with experimental inflammatory bowel disease. Mucosal Immunol. 2011;4:304–313.  http://dx.doi.org/10.1038%2Fmi.2010.75

Hontecillas R, Horne WT, Climent M, et al. Immunoregulatory mechanisms of macrophage PPAR-gamma in mice with experimental inflammatory bowel disease. Mucosal Immunol. 2011;4:304–313.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21068720

Howard MD, Willis L, Wakarchuk W, et al. Genetics and molecular specificity of sialylation of Histophilus somni lipooligosaccharide (LOS) and the effect of LOS sialylation on Toll-like receptor-4 signaling. Vet Microbiol. 2011.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21482041

Howard MD, Willis L, Wakarchuk W, et al. Genetics and molecular specificity of sialylation of< i> Histophilus somni lipooligosaccharide (LOS) and the effect of LOS sialylation on Toll-like receptor-4 signaling. Veterinary microbiology. 2011;153:163–172.  

Kale SD. Unraveling the Entry Mechanism of Oomycete and Fungal Effector Proteins into host cells. St. Paul, MN; 2011. Borlaug Global Rust Initiative Technical Workshop.  

Kale SD, Tyler BM. Assaying effector function in planta using double-barreled particle bombardment. In: Methods Mol Biol. Vol. 712.; 2011:153–172.  http://www.ncbi.nlm.nih.gov/pubmed/21359807

Lewis SN, Brannan L, Guri AJ, et al. Dietary α-Eleostearic Acid Ameliorates Experimental Inflammatory Bowel Disease in Mice by Activating Peroxisome Proliferator-Activated Receptor-γ. PLoS One. 2011;6:e24031.  http://dx.doi.org/10.1371%2Fjournal.pone.0024031

Lu P, Bevan D, Lewis SN, Hontecillas R, Bassaganya-Riera J. Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics. Journal of Molecular Modeling. 2011;17:543–553.  http://dx.doi.org/10.1007%2Fs00894-010-0748-y

Mazzei JC, Zhou H, Brayfield BP, Hontecillas R, Bassaganya-Riera J, Schmelz EM. Suppression of intestinal inflammation and inflammation-driven colon cancer in mice by dietary sphingomyelin: importance of peroxisome proliferator-activated receptor gamma expression. J Nutr Biochem. 2011.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21295961

Mazzei JC, Zhou H, Brayfield BP, Hontecillas R, Bassaganya-Riera J, Schmelz EM. Suppression of intestinal inflammation and inflammation-driven colon cancer in mice by dietary sphingomyelin: importance of peroxisome proliferator-activated receptor γ expression. The Journal of nutritional biochemistry. 2011;22:1160–1171.  

Plett JM, Kemppainen M, Kale SD, et al. Secreted effector protein of Laccaria bicolor is required for symbiosis development. Current Biology. 2011.  

Vroegrijk IOCM, van Diepen JA, van den Berg S, et al. Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice. Food and Chemical Toxicology. 2011;49:1426–1430.  

Wang Q, Han C, Ferreira AO, et al. Transcriptional Programming and Functional Interactions within the Phytophthora sojae RXLR Effector Repertoire. The Plant Cell Online. 2011.  http://www.plantcell.org/content/early/2011/06/07/tpc.111.086082.abstract

Wendelsdorf KW, Bassaganya-Riera J, Bisset K, Eubank S, Hontecillas R, Marathe M. ENteric Immunity SImulator: A tool for in silico study of gut immunopathologies. Atlanta, GA; 2011. IEEE International Conference on Bioinformatics and Biomedicine.  

2010


Bassaganya-Riera J, Hontecillas R. Dietary conjugated linoleic acid and n-3 polyunsaturated fatty acids in inflammatory bowel disease. Curr Opin Clin Nutr Metab Care. 2010;13:569–573.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20508519

Bassaganya-Riera J, Hontecillas R. Conjugated linoleic acid and n-3 PUFA in inflammatory bowel disease. Clinical Nutrition, Metabolic Care. 2010;13:569–573.  

Bassaganya-Riera J, Skoneczka J, Kingston DGJ, et al. Mechanisms of Action and Medicinal Applications of Abscisic Acid. Current Medicinal Chemistry. 2010;17:467–478.  http://www.ingentaconnect.com/content/ben/cmc/2010/00000017/00000005/art00006 http://dx.doi.org/10.2174/092986710790226110

Bassaganya-Riera J, Song R, Roberts PC, Hontecillas R. PPAR-gamma activation as an anti-inflammatory therapy for respiratory virus infections. Viral Immunol. 2010;23:343–352.  http://www.ncbi.nlm.nih.gov/pubmed/20712478

Chafin C, Muse S, Hontecillas R, et al. Deletion of PPAR-γ in immune cells enhances susceptibility to antiglomerular basement membrane disease. Journal of inflammation research. 2010;3:127.  

Chafin C, Muse S, Hontecillas R, et al. Deletion of PPAR gamma in immune cells enhances susceptibility to antiglomerular basement membrane disease. Journal of inflammation research. 2010;3:127.  http://www.dovepress.com/deletion-of-ppar-gamma-in-immune-cells-enhances-susceptibility-to-anti-peer-reviewed-article-JIR

Dou D, Kale SD, Liu T, et al. Different domains of Phytophthora sojae effector Avr4/6 are recognized by soybean resistance genes Rps4 and Rps6. Mol Plant Microbe Interact. 2010;23:425–435.  http://www.ncbi.nlm.nih.gov/pubmed/20192830

Dyer MD, Neff C, Dufford M, et al. The human-bacterial pathogen protein interaction networks of Bacillus anthracis, Francisella tularensis, and Yersinia pestis. PLoS One. 2010;5:e12089.  http://www.ncbi.nlm.nih.gov/pubmed/20711500

Evans NP, Call JA, Bassaganya-Riera J, Robertson JL, Grange RW. Green tea extract decreases muscle pathology and NF-kappaB immunostaining in regenerating muscle fibers of mdx mice. Clin Nutr. 2010;29:391–398.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19897286

Evans NP, Misyak SA, Schmelz EM, Guri AJ, Hontecillas R, Bassaganya-Riera J. Conjugated Linoleic Acid Ameliorates Inflammation-Induced Colorectal Cancer in Mice through Activation of PPAR gamma. The Journal of Nutrition. 2010;140:515–521.  http://jn.nutrition.org/content/140/3/515.abstract

Evans NP, Misyak SA, Schmelz EM, Guri AJ, Hontecillas R, Bassaganya-Riera J. Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARgamma. J Nutr. 2010;140:515–521.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20089779

Fu Z, Zhang W, Zhen W, et al. Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice. Endocrinology. 2010;151:3026–3037.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20484465

Guill S, Hargens T, Nickols-Richardson S, et al. Early evidence of increased risk for metabolic syndrome in young men with latent obstructive sleep apnea. Metab Syndr Relat Disord. 2010;8:33–38.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19943797

Guri AJ, Hontecillas R, Bassaganya-Riera J. Abscisic acid ameliorates experimental IBD by downregulating cellular adhesion molecule expression and suppressing immune cell infiltration. Clinical Nutrition. 2010;29:824–831.  http://www.sciencedirect.com/science/article/pii/S0261561410000397

Guri AJ, Hontecillas R, Bassaganya-Riera J. Abscisic acid synergizes with rosiglitazone to improve glucose tolerance and down-modulate macrophage accumulation in adipose tissue: Possible action of the cAMP/PKA/PPAR γ axis. Clinical Nutrition. 2010;29:646–653.  http://www.sciencedirect.com/science/article/B6WCM-4YJ140J-1/2/06ba39d85e868c00157bb562f89d34f6

Guri AJ, Hontecillas R, Bassaganya-Riera J. Abscisic acid synergizes with rosiglitazone to improve glucose tolerance and down-modulate macrophage accumulation in adipose tissue: possible action of the cAMP/PKA/PPAR gamma axis. Clin Nutr. 2010;29:646–653.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20207056

Guri AJ, Misyak SA, Hontecillas R, et al. Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4+ T cell recruitment into the aortic wall. The Journal of Nutritional Biochemistry. 2010;21:1178–1185.  http://www.sciencedirect.com/science/article/B6T8P-4Y7NDK4-4/2/e321470e157de1877d440745ea443f4e

Guri AJ, Mohapatra SK, Horne WT, Hontecillas R, Bassaganya-Riera J. The Role of T cell PPAR in mice with experimental inflammatory bowel disease. BMC gastroenterology. 2010;10:60.  

Guri AJ, Mohapatra SK, Horne WT, Hontecillas R, Bassaganya-Riera J. The role of T cell PPAR gamma in mice with experimental inflammatory bowel disease. BMC Gastroenterol. 2010;10:60.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20537136

Jesmin, Rashid M, Jamil H, Hontecillas R, Bassaganya-Riera J. Gene regulatory network reveals oxidative stress as the underlying molecular mechanism of type 2 diabetes and hypertension. BMC Medical Genomics. 2010;3:45.  http://www.biomedcentral.com/1755-8794/3/45

Kale SD, Gu B, Capelluto DG, et al. External lipid PI3P mediates entry of eukaryotic pathogen effectors into plant and animal host cells. Cell. 2010;142:284–295.  http://www.ncbi.nlm.nih.gov/pubmed/20655469

Lewis SN, Bassaganya-Riera J, Bevan DR. Virtual Screening as a Technique for PPAR Modulator Discovery. PPAR Res. 2010;2010:861238.  http://www.ncbi.nlm.nih.gov/pubmed/19746174

Mane SP, Dominguez-Bello MG, Blaser MJ, et al. Host-Interactive Genes in Amerindian Helicobacter pylori Diverge from Their Old World Homologs and Mediate Inflammatory Responses. Journal of bacteriology. 2010;192:3078.  

Mohapatra SK, Cole L, Evans C, et al. Modulation of hepatic PPAR expression during Ft LVS LPS-induced protection from Francisella tularensis LVS infection. BMC infectious diseases. 2010;10:10.  http://www.biomedcentral.com/1471-2334/10/10

Mohapatra SK, Guri AJ, Climent M, et al. Immunoregulatory Actions of Epithelial Cell PPAR γ at the Colonic Mucosa of Mice with Experimental Inflammatory Bowel Disease. PLoS One. 2010;5:e10215.  http://dx.doi.org/10.1371%2Fjournal.pone.0010215

Mohapatra SK, Guri AJ, Climent M, et al. Immunoregulatory actions of epithelial cell PPAR gamma at the colonic mucosa of mice with experimental inflammatory bowel disease. PLoS One. 2010;5:e10215.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20422041

Wendelsdorf K, Bassaganya-Riera J, Hontecillas R, Eubank S. Model of colonic inflammation: Immune modulatory mechanisms in inflammatory bowel disease. Journal of theoretical biology. 2010;264:1225–1239.  http://www.sciencedirect.com/science/article/B6WMD-4YRPF21-1/2/acbe519b946be6b46a2bd6b3c8c0ab01

2009


Bassaganya-Riera J, Ferrer G, Casagran O, et al. F4/80hiCCR2hi macrophage infiltration into the intra-abdominal fat worsens the severity of experimental IBD in obese mice with DSS colitis. e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism. 2009;4:e90–e97.  

Bassaganya-Riera J, Misyak S, Guri AJ, Hontecillas R. PPAR gamma is highly expressed in F4/80(hi) adipose tissue macrophages and dampens adipose-tissue inflammation. Cell Immunol. 2009;258:138–146.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19423085

Bassaganya-Riera J, Sanchez S, de Horna A, et al. F4/80hiCCR2hi macrophage infiltration into the intra-abdominal fat worsens the severity of IBD in obese mice with DSS colitis. e-SPEN Journal. 2009;4:90–97.  

Carter AB, Misyak SA, Hontecillas R, Bassaganya-Riera J. Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPARgamma. PPAR Res. 2009;2009:498352.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19390648

Evans NP, Misyak SA, Robertson JL, Bassaganya-Riera J, Grange RW. Dysregulated intracellular signaling and inflammatory gene expression during initial disease onset in Duchenne muscular dystrophy. Am J Phys Med Rehabil. 2009;88:502–522.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19454857

Evans NP, Misyak SA, Robertson JL, Bassaganya-Riera J, Grange RW. Immune-mediated mechanisms potentially regulate the disease time-course of duchenne muscular dystrophy and provide targets for therapeutic intervention. Pm R. 2009;1:755–768.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19695529

Hontecillas R, O'Shea M, Einerhand A, Diguardo M, Bassaganya-Riera J. Activation of PPAR gamma and alpha by punicic acid ameliorates glucose tolerance and suppresses obesity-related inflammation. J Am Coll Nutr. 2009;28:184–195.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19828904

Meerts IA, Verspeek-Rip CM, Buskens CA, et al. Toxicological evaluation of pomegranate seed oil. Food Chem Toxicol. 2009;47:1085–1092.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19425183

Qutob D, Tedman-Jones J, Dong S, et al. Copy number variation and transcriptional polymorphisms of Phytophthora sojae RXLR effector genes Avr1a and Avr3a. PLoS One. 2009;4:e5066.  http://www.ncbi.nlm.nih.gov/pubmed/19343173

Sassano G, Sanderson P, Franx J, Groot J, van Straalen J, Bassaganya-Riera J. Analysis of pomegranate seed oil for the presence of jacaric acid. Journal of the Science of Food and Agriculture. 2009;6:1046–1052.  

2008


Dou D, Kale SD, Wang X, et al. Conserved C-terminal motifs required for avirulence and suppression of cell death by Phytophthora sojae effector Avr1b. Plant Cell. 2008;20:1118–1133.  http://www.ncbi.nlm.nih.gov/pubmed/18390593

Dou D, Kale SD, Wang X, et al. RXLR-mediated entry of Phytophthora sojae effector Avr1b into soybean cells does not require pathogen-encoded machinery. Plant Cell. 2008;20:1930–1947.  http://www.ncbi.nlm.nih.gov/pubmed/18621946

Guri AJ, Hontecillas R, Bassaganya-Riera J. Dietary modulators of peroxisome proliferator-activated receptors: implications for the prevention and treatment of metabolic syndrome. J Nutrigenet Nutrigenomics. 2008;1:126–135.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19776622

Guri AJ, Hontecillas R, Ferrer G, et al. Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue. J Nutr Biochem. 2008;19:216–228.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17618105

Hontecillas R, Diguardo M, Duran E, Orpi M, Bassaganya-Riera J. Catalpic acid decreases abdominal fat deposition, improves glucose homeostasis and upregulates PPAR alpha expression in adipose tissue. Clin Nutr. 2008;27:764–772.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18778878

Thakare K, Shi W, Barbeau WE, Bassaganya-Riera J, Hontecillas R. Investigation of colorform-methanol soluble wheat proteins and sphingolipids as potential dietary triggers of diabetes in BBdp rats. Food and Agricultural Immunology. 2008;19:25–48.  

Tyler BM, Dou D, Kale SD, et al. The effector repertoire of Phytophthora sojae: structure, function and evolution. In: Lorito M, Woo S, Scala F, eds. Biology of Molecular Plant-Microbe Interactions. Vol. 6. St. Paul, Minnesota: International Society for Molecular Plant-Microbe Interactions; 2008.  

2007


Barbeau WE, Bassaganya-Riera J, Hontecillas R. Putting the pieces of the puzzle together?a series of hypotheses on the etiology and pathogenesis of type 1 diabetes. Medical hypotheses. 2007;68:607–619.  

Barbeau WE, Bassaganya-Riera J, Hontecillas R. Putting the pieces of the puzzle together – a series of hypotheses on the etiology and pathogenesis of type 1 diabetes. Med Hypotheses. 2007;68:607–619.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17045415

Bassaganya-Riera J, Guri AJ, Noble AM, et al. Arachidonic acid-and docosahexaenoic acid-enriched formulas modulate antigen-specific T cell responses to influenza virus in neonatal piglets. Am J Clin Nutr. 2007;85:824–836.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17344506

Guri AJ, Hontecillas R, Si H, Liu D, Bassaganya-Riera J. Dietary abscisic acid ameliorates glucose tolerance and obesity-related inflammation in db/db mice fed high-fat diets. Clin Nutr. 2007;26:107–116.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17000034

Hontecillas R, Bassaganya-Riera J. Peroxisome proliferator-activated receptor gamma is required for regulatory CD4+ T cell-mediated protection against colitis. J Immunol. 2007;178:2940–2949.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17312139

2006


Bassaganya-Riera J, Hontecillas R. CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD. Clin Nutr. 2006;25:454–465.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16698153

Bassaganya-Riera J, Hontecillas R. Modulation of CD8+ T cell Responses by Conjugated Linoleic Acid. In: Press AOCS, ed. Advances in CLA Research. Vol. 3. Champaign, IL; 2006:157–174.  

Guri AJ, Hontecillas R, Bassaganya-Riera J. Peroxisome proliferator-activated receptors: bridging metabolic syndrome with molecular nutrition. Clin Nutr. 2006;25:871–885.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17052808

2005


Bassaganya-Riera J, Guri A, King J, Hontecillas R. Peroxisome Proliferator-Activated Receptors: the Nutritionally Controlled Molecular Networks that Integrate Inflammation, Immunity and metabolism. Current Nutrition & Food Science. 2005;1:179–187.  

Hontecillas R, Bassaganya-Riera J, Wilson J, Hutto DL, Wannemuehler MJ. CD4+ T-cell responses and distribution at the colonic mucosa during Brachyspira hyodysenteriae-induced colitis in pigs. Immunology. 2005;115:127–135.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15819705

2004


Bassaganya-Riera J, King J, Hontecillas R. Health Benefits of CLA: Lessons from Pig Models in Biomedical Research. Eur. Journal of Lipid Science and Technology. 2004;106:856–861.  http://onlinelibrary.wiley.com/doi/10.1002/ejlt.200401067/pdf

Bassaganya-Riera J, Reynolds K, Martino-Catt S, et al. Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. Gastroenterology. 2004;127:777–791.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15362034

Bassaganya-Riera J, Thacker BJ, Yu S, Strait E, Wannemuehler MJ, Thacker EL. Impact of immunizations with porcine reproductive and respiratory syndrome virus on lymphoproliferative recall responses of CD8+ T cells. Viral Immunol. 2004;17:25–37.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15018660

O'Shea M, Bassaganya-Riera J, Mohede IC. Immunomodulatory properties of conjugated linoleic acid. Am J Clin Nutr. 2004;79:1199s–1206s.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15159257

2003


Bassaganya-Riera J, Pogranichniy RM, Jobgen SC, et al. Conjugated linoleic acid ameliorates viral infectivity in a pig model of virally induced immunosuppression. J Nutr. 2003;133:3204–3214.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14519812

Hontecillas R, Bassaganya-Riera J. Differential requirements for proliferation of CD4+ and gammadelta+ T cells to spirochetal antigens. Cell Immunol. 2003;224:38–46.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14572799

2002


Bassaganya-Riera J, Hontecillas R, Beitz DC. Colonic anti-inflammatory mechanisms of conjugated linoleic acid. Clin Nutr. 2002;21:451–459.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12468364

Bassaganya-Riera J, Hontecillas R, Wannemuehler MJ. Nutritional impact of conjugated linoleic acid: a model funtional food ingredient. In Vitro Cellular and Developmental Biology – Plant. 2002;38:241–246.  

Bassaganya-Riera J, Hontecillas R, Wannemuehler MJ. Nutrition impact of conjugated linoleic acid: A model functional food ingredient. In Vitro Cellular & Developmental Biology-Plant. 2002;38:241–246.  

Bassaganya-Riera J, Hontecillas R, Zimmerman DR, Wannemuehler MJ. Long-term influence of lipid nutrition on the induction of CD8(+) responses to viral or bacterial antigens. Vaccine. 2002;20:1435–1444.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11818164

Blanco JL, Hontecillas R, Bouza E, et al. Correlation between the elastase activity index and invasiveness of clinical isolates of Aspergillus fumigatus. J Clin Microbiol. 2002;40:1811–1813.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11980964

Hontecillas R, Wannemeulher MJ, Zimmerman DR, et al. Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid. J Nutr. 2002;132:2019–2027.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12097686

2001


Bassaganya-Riera J, Hontecillas R, Zimmerman DR, Wannemuehler MJ. Dietary conjugated linoleic acid modulates phenotype and effector functions of porcine CD8(+) lymphocytes. J Nutr. 2001;131:2370–2377.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11533281

Bassaganya-Riera J, Hontecillas-Magarzo R, Bregendahl K, Wannemuehler MJ, Zimmerman DR. Effects of dietary conjugated linoleic acid in nursery pigs of dirty and clean environments on growth, empty body composition, and immune competence. J Anim Sci. 2001;79:714–721.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11263832

2000


Waters WR, Hontecillas R, Sacco RE, et al. Antigen-specific proliferation of porcine CD8alphaalpha cells to an extracellular bacterial pathogen. Immunology. 2000;101:333–341.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11106936

1999


Waters WR, Pesch BA, Hontecillas R, Sacco RE, Zuckermann FA, Wannemuehler MJ. Cellular immune responses of pigs induced by vaccination with either a whole cell sonicate or pepsin-digested Brachyspira (Serpulina) hyodysenteriae bacterin. Vaccine. 1999;18:711–719.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10547431

Waters WR, Sacco RE, Dorn AD, Hontecillas R, Zuckermann FA, Wannemuehler MJ. Systemic and mucosal immune responses of pigs to parenteral immunization with a pepsin-digested Serpulina hyodysenteriae bacterin. Vet Immunol Immunopathol. 1999;69:75–87.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10490236

1996


Blanco JL, Guedeja-Marron J, Hontecillas R, Suarez G, Garcia ME. Microbiological diagnoses of chronic otitis externa in the dog. Zentralbl Veterinarmed B. 1996;43:475–482.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8921736

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