BLACKSBURG, Va., Aug. 8, 2004 - Dr. Reinhard Laubenbacher, research professor at the Virginia Bioinformatics Institute (VBI), and VBI graduate research assistant Brandilyn Stigler have had an article describing a computational approach to the study of gene regulatory methods published in the Journal of Theoretical Biology.
“A computational algebra approach to the reverse engineering of gene regulatory networks” was published in the August 24, 2004 edition of the journal. Using a time-discrete deterministic dynamic systems modeling framework the authors, Laubenbacher and Stigler, describe a technique of using microarray and other data to reverse engineer the structure of gene regulatory networks. Drawing from the rich theory of computational algebra the authors propose this innovative reverse engineering approach. Validation was done using a Boolean model of genes in the fruit fly. Their new method can be applied to discover regulatory relationships between the nodes in a gene regulatory network from a time series of experimental data.
The Journal of Theoretical Biology is the leading forum for theoretical papers that give insight into biological processes. It covers a very wide range of topics and is of interest to biologists in many areas of research. Many of the papers make use of mathematics, and an effort is made to make the papers intelligible to biologists as a whole.
August 24, 2004