Abstract: Erythritol is a preferential substrate for Brucella, a common zoonotic bacterial pathogen. This four-carbon polyol is found in the reproductive organs of several affected species, a feature that may account for the characteristic viscerotropism of Brucella that leads to sterility and abortion.
Although described previously as feeding glycolysis via dihydroxyacetone-phosphate, we shown recently that erythritol is actually converted into D-erythrose-4- phosphate through a hitherto undescribed set of reactions that involves three isomerases and that allows hexose-mono- phosphate synthesis and growth by feeding the pentose phosphate shunt. In addition of making the point on several historical aspects of the relationship between Brucella and Erythritol, this seminar will also unravel new data on the link between this polyol and the in vivo virulence in a mice model of infection.
1. PNAS, "Erythritol feeds the pentose phosphate pathway via three new isomerases leading to D-erythrose-4-phosphate in Brucella"
2. FEBS Letters, "Brucella adaptation and survival at the crossroad of metabolism and virulence"