Abstract: The recent spread of Zika virus (ZIKV) and its association with increased rates of Guillain Barre and other neurological disorders as well as congenital defects that include microcephaly has created an urgent need to develop animal models to examine the pathogenesis of the disease and explore the efficacy of potential therapeutics and vaccines. Recently developed infection models for ZIKV utilize mice defective in interferon responses.

This talk will describe a new model of peripheral ZIKV infection using immunocompetent neonatal C57BL/6 mice and compare its clinical progression, virus distribution, immune response, and neuropathology with that of C57BL/6-IFNAR KO mice.

Suggested Readings: 

  1. CD4 and CD8 T Cells Mediate Distinct Lethal Meningoencephalitis in Mice Challenged With Tacaribe Arenavirus
  2. Zika Infection is Associated with T Cell Infiltration and Neurodegeneration in CNS of Immunocompetent Neonatal C57Bl:6 Mice