Dr. Mao's primary research interests focus on developing and applying bioinformatics software and databases for biological data management, data integration, data mining, data curation and data analysis. Dr. Mao played a leading role in developing several databases, tools and web applications: 1) ESTAP: an EST analysis pipeline; 2) NodMutDB: a comprehensive database and a web interface for genes and mutants involved in symbiosis; 3) RhizobialesBRC: an integrated bioinformatics resource for rhizobia-legume symbiosis research; 4) TEfam: a relational database and a web interface for submission, retrieval, and analysis of transposable elements in mosquitoes; 5) Disease View, an online host-pathogen resource that enables infectious disease-centric access, analysis and visualization of host-pathogen interactions. She is also involved in developing PATRIC, the bacterial bioinformatics database and analysis resource funded by NIAID. In addition to software and database development, she has extensive experience in analyzing genomics, transcriptomics and proteomics data. For example, she led two of the PATRIC’s driving biology projects: the comparative ’omics analysis of divergent Clostridium difficile strains and identification of Salmonella-specific regulatory networks using RNA-Seq and ChIP-Seq. She is also a project manager of NHLBI funded project on Genomic and Proteomics Architecture of Atherosclerosis (GPAA). She manages the team effort on proteomics analysis, exome sequencing analysis and RNA-Seq analysis of the GPAA data.