Abstract: A vaccine with broad protective efficacy is considered an essential tool to eradicate malaria, a disease that kills close to half a million people each year. Both subunit and whole organism-based vaccines currently being tested have demonstrated incomplete protection against heterologous challenge and against natural infection, as a result of allele- or strain-specific vaccine efficacy. One approach to broaden vaccine protective efficacy is to generate multivalent malaria vaccine formulations. In this presentation, I will describe tools, resources and data that my group is generating with the goal of informing the design of malaria vaccines that overcome strain-specificity.
Speaker Bio: Joana Carneiro da Silva is an Associate Professor of Microbiology and Immunology in the Institute for Genome Sciences, at the University of Maryland School of Medicine. Her research focuses on single-celled eukaryotic parasites, with particular emphasis on organisms in the phylum Apicomplexa. These include the causative agents of malaria in humans (genus Plasmodium), theileriosis and East Coast fever in cattle (genus Theileria), human and bovine babesiosis (genus Babesia), and cryptosporidiosis in vertebrates, including humans (genus Cryptosporidium).